Fecha/hora: 01/06/2024 09:57:15

Biblioteca(s): 	INIA Tacuarembó.	
Tipo de la producción científica: 	Artículos en Revistas Indexadas Internacionales	
Circulación/Nivel: 	Internacional - --	
Fecha corriente: 	01/09/2020	
Fecha de la última actualización: 	01/09/2020	
Autoria: 	MACHADO, M.; CASTRO, M.B; GIMENO, E.J.; BARROS, S.S.; RIET-CORREA, F.	
Afiliación: 	MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARCIO B. CASTRO, Laboratorio de Patologia Veterinaria, Universidade de Brasília, Brasília, Brazil; EDUARDO J. GIMENO, Faculdad de Ciencias Veterinarias, National University of La Plata, Argentina; SEVERO S. BARROS, Laboratorio de Patologia Veterinaria, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.	
Título: 	Enzootic calcinosis in ruminants: A review.	
Año de publicación: 	2020	
Fuente/Imprenta: 	Toxicon, 2020, volumen 187, Pages 1-9. Doi: https://doi.org/10.1016/j.toxicon.2020.08.009	
DOI: 	10.1016/j.toxicon.2020.08.009	
Idioma: 	Inglés	
Contenido: 	ABSTRACT: Enzootic calcinosis (EC), is a chronic disease, caused by toxic plants, which has mainly affected ruminants for more than 100 years. It is characterized by a soft tissue calcification, hypercalcemia, hyperphosphatemia, hypoparathiroidism, hypercalcitoninism, osteonecrosis, and osteopetrosis. The toxic compound reported in some of these plants are 1,25(OH)2D3 glycosides. Characterization of calcinogenic principles were performed with Solanum glaucophyllum, Trisetum flavescens, Cestrum diurnum, and Stenotaphrum secundatum. Other plant species involved in EC are: Nierembergia rivularis, Nierembergia veitchii, Solanum torvum, and Solanum stuckertii. Clinical and pathological findings are well characterized. We present different aspects of the pathogenic mechanism of EC, including genetic modulation, expression of bone proteins, cellular de-differentiation of arterial smooth muscle cells, phenotypic changes, production of a calcifiable matrix, and modulation of the calcium and phosphorus balance. The use of comparative pathology can bring significant advances in the understanding of the pathogenic mechanism. In this review we present a broad approach to the different aspects of intoxication: history of EC on different continents; plant species, distribution and morphology; toxic principle; pathogenesis; epidemiology; clinical signs; diagnosis; and control and prophylaxis.	
Palabras-Clave: 	CALCINOGENIC PLANTS; CALCINOSIS ENZOÓTICA; ENZOOTIC CALCINOSIS; INTOXICACIÓN; PATHOGENESIS; PLANTAS TÓXICAS; RUMIANTES; VITAMIN D; VITAMINA D.	
Categoría del tema: 	L01 Ganadería	
Registro original: 	INIA Tacuarembó (TBO)	
Ejemplares: 	TBO - (103242-1) - PXI - AP - DD -  -  -  - DIS